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In phase 2 clinical trials, people with obesity who used MariTide achieved up to 20% weight loss after one year, along with significant improvements in blood sugar levels and other metabolic markers

However, brand-name medications are currently available, and compounding is only allowed when the patient needs a customized dosage or formulation that is not commercially available

NNMT inhibition may actually improve the adipocytes capacity to oxidize fat by restoring the NAD+-dependent sirtuin activity and mitochondrial function that fatty acid oxidation requires

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The endpoint of the trial was reached when the tumors grew to the size limit (15 mm in diameter)